Endocrine Abstracts

Introduction: The debate surrounding the most suitable pituitary provocation test in children is controversial. There is a perception that the gold standard insulin tolerance test (ITT) is ‘dangerous’ and that the glucagon stimulation test (GST) is ‘safer’ and a more tolerable alternative, particularly in younger children. There have been no reports in the literature comparing patient experiences of these tests.Aim: To examine the tol...

Background: Oxidative stress has been implicated in the development and progression of complications in type 1 diabetes (T1DM). Vitamin E (α-tocopherol) undergoes β-oxidation of its chomanol ring and the resulting metabolite α-TLHQ has been proposed as a potential biomarker of oxidative stress. HbA1c relates in T1DM to microvascular complications predominantly although the end-points are late in disease development. The oxidative stress process may act independe...

Introduction: Pituitary adenomas (PAs) account for <3% of all paediatric supratentorial tumours. Despite being benign, they can cause significant tumour- and treatment-related neuroendocrine and visual morbidity. Patients may be the index case for syndromes such as multiple endocrine neoplasia type 1 (MEN1).Case report: Patient R was referred at 11.9 years with longstanding headaches and bilateral visual deterioration to the point of near-blindness. ...